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Jan Marini Skin Research, Inc. was founded by Jan Marini, product research and glycolic acid pioneer. The company is comprised of technological breakthroughs and formulations previously unavailable. Jan Marini Skin Research advocates a focused result-oriented approach to skin care management. The line includes a full range of advanced glycolic based products, the revolutionary Vitamin C breakthrough C-ESTA, TGF Beta-1 (Transforming Growth Factor), antioxidants, proteolytic enzymes and other therapeutic agents.

SkinSpirit offers selections from the following Jan Marini product groups:

C-ESTA GROUP

 
    Jan Marini Skin Research C-ESTA containing DAE Complex, is a revolutionary concept in anti-aging based on the first topical form of lipid soluble Vitamin C that is stable and able to be absorbed. C-ESTA is the culmination of years of intensive medical research by Nicholas Perricone, M.D. that has resulted in a patented delivery vehicle, combined with other essential stimulatory factors, that can actually address the appearance of sagging and redundant tissue.

It is an established fact that Vitamin C plays an essential role in every aspect of the skin's functioning including growth, maintenance and repair of connective tissue, protection from free radical oxidation damage, wound healing, collagen synthesis, and prevention of premature aging.

Considering the critical role Vitamin C plays in every aspect of youthful healthy skin, it is important to remember that humans cannot manufacture Vitamin C. In humans, the total pool of Vitamin C is 1500 mg. The average person must have a continuous intake of Vitamin C in order to maintain bodily functions. Skin is especially vulnerable to Vitamin C deficiency because Vitamin C is pulled from the skin to maintain other bodily functions. Physical or emotional stress causes even greater quantity of Vitamin C to be depleted from the skin.

Stabalization and Absorption
Under clinical laboratory conditions, scientists are able to cause collagen synthesis as well as stimulate skin rejuvenation by transporting Vitamin C into cells. The obstacle to incorporating this into practical application is stabilization and absorption. First, Vitamin C in a topical product degrades or completely loses its potency very easily, especially when exposed to sun or heat.

This means that shelf life would be so short that it would be impossible for commercial marketing. Second, it is well recognized that Vitamin C is not readily absorbed through the skin, so even if high concentrations could be stabilized, the effectiveness would be minimal because it would only absorb into the outermost layers of the stratum corneum.

Jan Marini Skin Research has formulated C-ESTA using DAE Complex. This complex is the key to stabilization, absorption, and the ability to produce results beyond any skin care advancement currently available. C-ESTA containing DAE Complex also incorporates a second breakthrough discovery that addresses the appearance of redundant tissue. This technology is part of the DAE Complex and involves research on neurotransmitters. Neurotransmitters are chemicals that allow the brain's messages to be executed into muscle movement. They are also responsible for youthful muscle tone that assists in maintaining firm facial contours. Medical studies have resulted in a revolutionary topical agent that when combined with Vitamin C results in the stimulation of certain neurotransmitters. This process actually addresses areas of facial sagging such as nasolabial folds, the forehead and jawline jowling.

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BIOGLYCOLIC GROUP

 
    Glycolic acid is what is known as an "alpha hydroxy acid". Alpha hydroxy acids or "AHAs" are a family of acids that occur naturally in various fruits and foods. Glycolic acid, found in sugar cane, is the AHA that has received the most attention medically because of all the AHAs, it has the smallest molecule. This small molecular weight enables glycolic acid to penetrate more effectively and to ultimately bring about the most dramatic and beneficial changes of all the AHAs, often collectively referred to as fruit acids.

Among other things, glycolic acid loosens the "glue-like" attachments, or cellular cement, that are characteristic of many skin conditions such as acne, photo damage (environmental aging), and hyperpigmentation. This non-invasive lifting of the cells in the stratum corneum enables glycolic acid to act as a phenomenal resurfacing agent that can immensely improve the appearance of the skin. It has even proven to be a valuable tool in reducing the depth of acne scarring.

As physicians and researchers have developed a greater interest in glycolic acid, medical studies have revealed that glycolic acid stimulates collagen, increases epidermal volume and even acts as a powerful antioxidant and free radical inhibitor. Tests also illustrate how glycolic acid acts as a delivery agent when combined with other beneficial ingredients or medications, thus potentiating the desired results.

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ANTIOXIDANT GROUP

 
    Tremendous interest and research is currently being focused on antioxidants and their value in helping to reverse and prevent free radical damage. By definition, free radicals are highly unstable oxygen molecules with unpaired electrons that must seek other molecules with stable electrons to achieve their own stabilization. Attaching to the stable electrons of other molecules accomplishes stability, but as a result the "good" molecule is then transformed by the free radical into another free radical whose function and shape is now altered. Free radicals work quickly. In mere seconds, one free radical can trigger a chain reaction that produces thousands of additional free radicals.

The damage caused by the free radicals can range from cell damage to the ultimate of cell death. Such cellular breakdown manifests itself superficially in lines, wrinkles, dry skin, loss of elasticity, and skin discoloration. On a deeper level, free radical destruction can substantially destroy the collagen and elastin support system, degrade DNA, damage vital enzymes, impair critical immune functions, and cause general tissue deterioration.

Certain substances termed as antioxidants have the capability of interrupting or even preventing this cellular onslaught. Another term for antioxidants is free radical scavengers. The term scavenger refers to their ability to provide electrons so that the free radical can attach itself to the antioxidant electron and be rendered harmless before it can attach itself to a so called "healthy" radical and begin the destructive chain reaction.

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BENZOYL PEROXIDE GROUP

 
    Benzoyl peroxide is a potent and effective therapy for treating acne. It is currently recognized by the American Academy of Dermatology as being one of the most effective antibacterial agents proven to significantly reduce the presence of P acne bacteria (the bacteria believed to play a primary role in the inflammatory aspect of the acne process).

P acne bacteria thrives in an oxygen free environment and feeds on trapped oil in the sebaceous follicle. It then releases a toxic, corrosive, fatty acid by-product that works to break down the follicle walls and encourage the leaks and ruptures that produce acne lesions. By reducing the P acne bacteria colonies, the inflammatory process is minimized and clearing of acne lesions is greatly enhanced.

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GENZYME THERAPY GROUP

 
    Proteolytic enzymes are the most scientifically sensible and effective method to accomplish supplemental exfoliation at home. Simply defined, the term "proteolytic" refers to an enzymatic reaction that can digest dead or diseased protein material without harming living healthy cells. Unlike abrasive scrubs or other mechanical methods, proteolytic enzymes are selective and therefore the patient is less likely to cause irritation from pressure or over manipulation.

A commonly used proteolytic enzyme is papain, often found in tropical fruits such as papaya. The most potent form of papain exists in green unripened papaya. As the papaya ripens, the enzyme activity declines considerably. In fact, green unripened papaya can be 50 to 100 times stronger than other forms of papain.

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